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Yu Z Zhang B, Cui B, Wang Y, Han P, Wang X (2012) Identication of spliced variants of theproto-oncogene HDM2in colorectal cancer. Itsmajor limitation is higher incidence of agranu-locytosis (0.8%) and other blood dyscrasias:weekly monitoring of leucocyte count is required.Metabolic complication like weight gain,hyperlipidemia and precipitation of diabetes isanother major limilation. Some studies haveshown that experimental subjects have experienced both anger and sadnesswhen faced with irretrievable loss

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