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In the spontaneous/timed mode,the ?ow trigger feature is activated; the ventila-tor cycles in the timed mode only in the eventof prolonged apnea or low minute ventilation.Paediatric patients are most often managed withNPPV in the spontaneous/timed mode. The signal sequence is cleaved fromthepolypeptide by signal peptidaseresiding on the cisternal faceof the rER membrane, even before the synthesis of the entirechain is completed. In addition, many are unable to report abuse, forfear of reprisal (Lindbloom et al., 2007). The social, psychological, and spiritual consequences of alonenesswhile dying do not appear to have a ready set of easy explanations for theoften perplexing, frightening, or ecstatic emotional experiences that dyingpeople commonly experience

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